The Nexera XS inert UHPLC offers the ideal solution for the separation of biopharmaceuticals such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and nucleic acid drugs with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion. The Nexera XS inert supports analytical method development, method scouting and quality control by incorporating the high-pressure tolerance of UHPLC for SEC, IEX, and HIC workflows. Mobile phases containing high haloid salt concentrations or extreme pH levels can be seamlessly handled using the Nexera XS inert.
The Nexera XS inert prevents target component recovery rates from decreasing by inhibiting adsorption caused by interactions between metal ions and proteins, nucleic acids, or other components. Phosphorylated peptides and other molecules with a strong tendency to adsorb to metals can be easily detected using the inert UHPLC. Proprietary technology that minimizes exposure to metal ions on internal surfaces, inhibits adsorption of target molecules within sample flow channels, ensuring good peak shape, and excellent separation.
Nexera XS inert systems eliminate the need for the preliminary passivation and provide highly reliable data right from the first injection and throughout the analytical session. Wider dynamic range coupled with higher operational accuracy in low-concentration regions by minimizing adsorption and carry over further enhance the quality of data.
