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Simultaneous Analysis of API and Related Impurities Using SPD-M40 X4 Photodiode Array Detector

Reliable Peptide Mapping with Nexera X4 -Excellent Reproducibility under Shallow Gradient Conditions Spincotech

Achieving Sharp Peaks and High Sensitivity with Nexera X4

Achieving Solvent Reduction and Lower Running Costs with Nexera X4

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Nexera X4 Series

Nexera X4 Ultra High-Performance Liquid Chromatograph Spincotech

Ultra High Performance Liquid Chromatograph

Next-generation Nexera X4 UHPLC achieves an incomparable level of analytical performance through cutting-edge fluid control technology providing exceptional solvent delivery consistency, even for fast analysis under ultra-high-pressure conditions.

Ultra-Sharp Peaks

Nexera X4 UHPLC Systems incorporate proprietary Nexflow technology achieving the lowest degree of peak broadening* in the industry without changing the internal diameter of the flow lines resulting in ultra-sharp peaks and outstanding separation performance. An overall increase in column performance by minimizing broadening of sample peaks outside the column improves the theoretical plate numbers even for analytes which are weakly retained.

Impurities in a pharmaceutical sample Maximized column performance
Impurities in a pharmaceutical sample
Maximized column performance Spincotech
Maximized column performance
Ultra-fast Analysis
Four independently actuated plungers and a pressure feedback mechanism significantly improve solvent delivery responsiveness and enable ultra-fast analysis. Analysis times are 92 %.

and 78% shorter compared to those with typical HPLC and existing UHPLC-like systems, respectively, resulting in up to 14 times higher laboratory productivity. Superior gradient reproducibility coupled with highly consistent solvent delivery results in excellent retention time reproducibility.

Dramatically shortened run times Spincotech
Dramatically shortened run times
Consistent results even for Ultra-fast gradients Spincotech
Consistent results even for Ultra-fast gradients
Ultra-Low Solvent Consumption

Through analytical miniaturization, exceptionally low solvent quantities are consumed while maintaining superior analytical performance.

Analytical Miniaturization at its best Spincotech
Analytical Miniaturization at its best
Solvent Consumption (at 800 analysesmonth) Spincotech
Solvent Consumption (at 800 analysesmonth)

Micro-injection   –   Good repeatability with even 1µL injections

Highly precise solvent delivery – Small internal volumes enable gradient runs with microbore columns

Reduced Peak broadening – Nexflow technology offers sharp peaks

Best Partner for Mass Spectrometry

LCMS-8060RX triple quad coupled featuring positive and negative ionization switching in 5 msec with UFswitching™ technology in combination with Nexera X4, offers the next-generation LC-MS platform that delivers unmatched throughput and reliability. The platform is ideal for pharmacokinetic analytical workflows where fast, reliable analysis are of prime importance.

High Performance LC-MSMS Analysis Spincotech
High Performance LC-MSMS Analysis