Enhance your early stage solid state screening with the CrystalBreeder bench-top system. Enhanced with new controlled evaporation and vapor diffusion modules.
CrystalBreeder is the next generation multi-reactor crystallization platform for medium-throughput solid-state research, operating at working volumes of 0.1 mL. Run rapid complete crystallization screens with as little as 1 mg of sample. CrystalBreeder provides real time turbidity readings for 32 parallel temperature controlled experiments. When early solubility information is essential, stop guessing and let CrystalBreeder put you in the lead.
CrystalBreeder is the next generation multi-reactor crystallization platform for medium-throughput solid-state research, operating at working volumes of 0.1 mL. Run rapid complete crystallization screens with as little as 1 mg of sample. CrystalBreeder provides real time turbidity readings for 32 parallel temperature controlled experiments. When early solubility information is essential, stop guessing and let CrystalBreeder put you in the lead.
To decrease the time to market, effective innovation is vital. Early-stage solid-state screening is necessary to avoid costly developmental surprises later. Similarly, there is a requirement for salt screening early on in the development process, since changing salt form at a later stage may cause costly delays to the entire process.
Investigate small amounts of sample under controlled conditions, with CrystalBreeder: simply and reliably. Complete a salt screen with as little as 1 mg of compound at working volumes of 0.06 – 0.1 mL. Top stirring is now available with CrystalBreeder and was specifically developed to overcome attrition issues.
Reaction conditions are more reproducible and realistic than in well-plate experiments, whilst in vial analytics measure turbidity in each reactor without physical contact with the sample. Real-time display of turbidity provides an immediate and reliable signal when a sample crystallizes.
The reaction vials are fully compatible with liquid handling and solid dosing robots, ensuring quick, easy and reproducible sample preparation. Using the handy CrystalBreeder caps, the reaction vials can be loaded into the CrystalBreeder with ease. With an intuitive software interface, the system controls and analyzes 32 reactors, with 8 independent temperature zones. Screening experiments are set up in less than a minute, using predefined protocols.
Investigate small amounts of sample under controlled conditions, with CrystalBreeder: simply and reliably. Complete a salt screen with as little as 1 mg of compound at working volumes of 0.06 – 0.1 mL.
Top stirring is now available with CrystalBreeder and was specifically developed to overcome attrition issues. Reaction conditions are more reproducible and realistic than in well-plate experiments, whilst in vial analytics measure turbidity in each reactor without physical contact with the sample. Real-time display of turbidity provides an immediate and reliable signal when a sample crystallizes.
CrystalBreeder was designed with versatility in mind. Use overhead stirring with a unique hook design to mix thick slurries and viscous fluids. CrystalBreeders Evaporation set-up facilitates fully controlled evaporation crystallization studies. You can also directly dry your samples without using a separate evaporator.
Vapor diffusion crystallization is now available, utilizing the unique vapor diffusion set-up. You are no longer limited by the boiling point and vapor pressure of the solvent and anti-solvent. This broadens the design space much more than classical vapor diffusion methods.
The new modules offer vapor diffusion and evaporation capabilities, increasing the instrument’s versatility, and facilitating more advanced experiments.
The two modules sit on top of the CrystalBreeder, maintaining a compact footprint. Users control the temperature, heat/cool rate, stirring speed and evaporation pressure for all disposable block reactors with the software, generating accurate solubility and crystallization data in a short time.
| Specifications | CrystalBreeder |
| Feedback control | Yes |
| Reactors | 32 |
| Reactor type | Commercially available, glass |
| Optimal work volume (mL) | 0.06 to 0.1 |
| Temperature zones | 8 |
| Temperature range (°C) | -15 to 1501 |
| Temperature accuracy (°C) | 0.1 |
| Heating rate (°C/min) | 0 – 20 |
| Cooling rate (°C/min) | 0 – 20 |
| Stirring | Overhead or stirrer bar |
| Stirring speed (rpm) | 0 – 1250 |
| Evaporation option | Yes, with evaporation flow per block of 4 reactors |
| Vapor diffusion option | Yes |
| Turbidity (%) | Every reactor |
| Chiller necessary (°C) | No |
| Data export | CrystalClear, Word Report, XML |
| Footprint (DxWxH) | 49x56x20 |
