Voglibose, a common antidiabetic drug does not show UV absorption. The Japanese Pharmacopoeia (JP) 17th Edition describes the monographs (purity test for voglibose, assay for voglibose tablets) using the HPLC post-column fluorescence derivatization method with a taurine/sodium periodate reagent.
The CRB-40 (Chemical Reaction Box) used as a key element in the voglibose analysis system is a reactor compatible with a variety of post-column reaction conditions with temperature settings up to 150°C. Excellent temperature stability contributes to stable post-column reactions and improves the reliability of quantitative values. The CRB-40 is simple to operate with LabSolutions and data integrity is supported through temperature and operation logging.
Parameters related to separation and detection (LC) and the temperature of the chemical reaction box are managed by the same method using LabSolutions. The whole work flow from device startup to shutdown can be carried out through LabSolutions. The analysis method, operation log, and equipment status are managed as one, linked through the analysis results. The system including the reactor is designed to ensure data integrity.