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An Ultra-high Sensitivity Analysis of 29 PFAS Compounds in Drinking Water by Direct Injection

Breakthrough Sensitivity and Robustness for PFAS Analysis for EPA Method 1633A Spincotech

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LCMS-8065XE

LCMS-8065XE Spincotech

Triple Quadrupole LC-MS/MS

The new LCMS-8065XE is a triple-quadrupole mass spectrometer with EVOLVED, EFFICIENT, and EXACT capabilities resulting in high reliability and enhanced productivity, empowering the laboratory for the future.

EVOLVED: Embrace the power of StreamFocus ionization  
EFFICIENT: Exceptional throughput, outstanding ROI
EXACT: Exceptional accuracy and enhanced sensitivity

Core of High-Sensitivity Analysis

The newly designed StreamFocus ESI probe enhances UFsensitivity™ analysis by reducing droplet dispersion within the ESI spray. Equipped with a specially engineered low-diffusion nebulizer nozzle, it enables greater ion intake while reducing nebulizer gas consumption – reducing operational costs.

Exploring the Core of High-Sensitivity Analysis Spincotech
UF Technologies Enable Ultra-Fast Applications

Shimadzu’s proprietary UFsweeper™ technology – designed to efficiently guide ions through the collision cell without energy loss – has been further refined. The updated collision cell features a larger entrance lens diameter and an increased number of lenses, significantly boosting ion throughput. These improvements result in enhanced ion transmission and greater sensitivity, enabling more precise and reliable quantitative analysis.

UFsweeper™ Ⅳ Spincotech
PERFORMANCE CONCIERGE & Automated MRM

A tuning standard is automatically introduced into the instrument to verify parameters, including mass accuracy, resolution, and signal strength. Should the criteria not be met, PERFORMANCE CONCIERGE will diagnose the issue and alert the operator of required maintenance and maximize uptime.
Automated MRM optimization creates high sensitivity quantitative LC-MS/MS methods. LabSolutions Connect MRM not only optimizes target component MRM transitions and collision energies but also maximizes the response for on column analysis. All optimized acquisition parameters are stored in a data base accelerating method development and routine analysis.

Accurate Data Analysis, Reporting Results

Peakintelligence for LC-MS is a world-first AI driven peak integration algorithm requiring zero user settings. The impact is dramatic. Peakintelligence for LC-MS delivers higher consistency in peak integration and results in higher data quality and with far less time manually reviewing data. Accurate peak integration even for low signal-to-noise ratios is facilitated by the intelligent algorithm. Compounds such as PFAS are detected at parts-per-trillion delivering exceptional sensitivity.

Reduce Time Consuming Spincotech
pfhxa Spincotech
EXACT Spincotech

LabSolutions Insight supports a dynamic quantitative data review landscape with the tools to drive high confidence in result reporting by ‘review by exception’. Insight can be configured to check for any outliers outside the scope of user defined criteria for reporting results.

Easy Maintenance

Changing the ESI capillary and the desolvation line (DL), which transports ions into the vacuum region, are designed for quick and effortless replacement without breaking vacuum helping to reduce time spent on maintenance and increase instrument uptime.

Championing Sustainability

LCMS-8065XE includes ecology mode functionality that checks the system usage status and automatically shuts down the system if it has not been used for a certain period of time. Using the ecology mode can reduce electricity consumption by about 31%. It also contributes significantly to reducing power consumption by not using LC-MS/MS peripheral equipment except during analysis.