Loss of CCI can occur due to component defects (cracks in glass, out-of-specification vial/stopper dimensions or improper vial/stopper combinations) or process defects (displaced stoppers prior to capping, misaligned tooling, rough handling).
Laser-based headspace leak detection systems from Syntegon powered by LIGHTHOUSE measurement technology enables rapid automated in-line leak detection by monitoring changes in headspace changes in total headspace pressure.