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Analysis of Oligonucleotide Therapeutics using MALDI-8030 and LCMS-9030

Negative Mode Analysis of Synthetic Oligonucleotides usingthe MALDI-8030 Dual Polarity BenchtopMALDI-TOF Mass Spectrometer

Performance Evaluation of Microbial Identification Using a Benchtop MALDI-TOF MS

QualityControlof SyntheticPeptides usingthe MALDI-8030 DualPolarity BenchtopMALDI-TOF Mass Spectrometer

Sequence Analysis of Antisense Oligonucleotides Using a MALDI-8030 Benchtop MALDI-TOF Mass Spectrometer

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MALDI - 8030

MALDI - 8030 Spincotech

Dual Polarity Benchtop Linear MALDI-TOF Mass Spectrometer

MALDI-8030 delivers outstanding performance in a compact footprint. Patented WideBore™ Ion Optics technology significantly reduces contamination from the desorbed MALDI sample. To maximize uptime, the system is equipped with TrueCleanTM – an automated, rapid (<10 min) UV laser-based source cleaning technology which can be used to clean the extraction electrode in-situ without breaking instrument vacuum. ‘No maintenance, oil-free’ diaphragm pump and no dependence on desiccants save on costs while the HD camera allows best visibility of sample spots. Dual-polarity ion source in the MALDI-8030 allows the flexibility to analyse oligonucleotides in negative mode (main spectrum), resulting in a cleaner mass spectrum compared to positive ion mode containing adducts.

  • Dual mode (+ve / -ve ion) for intact mass
  • Mass range up to m/z 500,000
  • Automated lock mass feature: highly suitable for biosimilars
  • 200 Hz solid-state laser, 355 nm
  • <20 ppm accuracy (with internal calibration)
  • Staked with Technology, Designed for Performance

Integrated barcode reader when used with FlexiMass™-DS slides (requires AuraSolutionTM software) reduces pre-analytical misidentification errors. The single-use FlexiMass-DS disposable slides provide a convenient solution for routine or defined workflows. Alternatively, the reusable stainless steel FlexiMass-SR sample targets provide a cost-effective, longer-term solution to sample preparation.

Best-in-class Sensitivity And Resolution Spincotech
Best-in-class sensitivity and resolution

MALDI-8030 has been used successfully in melanoma screening based on differences in extracted lipid profiles, showing the potential of this approach as a rapid biomarker screening tool. MALDI Solutions™ software features a centralized, secure Microsoft® SQL database which can be used to store everything from sample lists and acquisition Parameter Sets to acquired MALDI data.

Peptidfe QC in Biopharma

MALDI-8030 is ideal for both quality control (QC) and profiling workflows – peptides, proteins, clinical sample profiling, polymers or oligonucleotides – the system delivers superior performance for all through rapid and accurate mass measurements. Quite a few promising additional applications of MALDI-8030 include : analysis of pigments in cosmetics/lipsticks, regulated food colourants in sweets/candies, adulterants extra virgin olive oil, etc,.