Inheriting the concept of a mass spectrometer equipped with an optical microscope from the iMScope series, the iMScope QT is also Shimadzu’s flagship model for MS imaging with a Q-TOF MS (LCMS-9030). The iMScope QT boasts not only fusion with morphology studies but also excellent speed, sensitivity, and spatial resolution, clearing the way to next-generation mass spectrometry imaging.
Total System for MS Imaging Analysis
Mass spectrometry imaging is performed in three steps: pretreatment, data acquisition, and data analysis. At each step, the optimal approach accelerates research, while improving the reliability of the results.
Fusion of observations from an optical microscope with MS images (exclusive to Shimadzu) . MS images can be obtained flexibly and matched to observation images, either the entire image area or detailed portions of it.
Measurement Results for the Cerebellum with 5 μm Spatial Resolution
- Sample ：Whole mouse brain
- Matrix ：9-AA
- Measurement region ：662×595（393890pix）
- Measurement time: ：around 2.2 hours
- The region in the red frame below (cerebellum) was measured with a resolution of 5 μm. High-resolution MS imaging and morphological observations with the optical microscope support cutting-edge research.
- Sample:Whole mouse brain
- Matrix ：9-AA
- Measurement region: ：1126×624（702624pix）
- Measurement time：around 6 hours
The sections of the mouse brain (17 mm × 9.4 mm) were measured at high resolution with a 15 μm pitch (702,624 pixels). The high-resolution analysis of these large brain sections was completed in around 6 hours, enabling testing to proceed efficiently.
Quantification and Distribution
Obtain qualitative and quantitative information from LC-MS as well as position information from mass spectrometry imaging (MSI) with a single instrument.
The combined system, which can perform LC-MS analysis in addition to MSI analysis, provides both distribution information and quantitative analysis.