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SP Hull LyoConstellation S80/S100/S130 Production Lyophilizers

Finding the right lyophilizer for your fill-finish workflow can be troublesome and time-consuming. Handle high-value API’s safely and efficiently with our range of SP Hull LyoConstellation™ Production Lyophilizers – specifically designed for aseptic operation. With a comprehensive range of options including controlled ice nucleation, fluid condenser cooling and more, we’ve done the hard work, so you don’t have to.

  • Get to market faster – optional SP Hull Row-by-Row (RxR-36) loading system for high throughput
  • Integrate with ease – compatible with SP i-Dositecno filling line and automatic loading system
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Our SP Hull LyoConstellation™ S80, S100 and S130 Production Lyophilizers build on SP’s reputation as a pioneer of freeze-drying technologies. Equipped and controlled as a production system, the LyoConstellation offers a seamless approach to scale-up while being designed for line integration. If time is not on your side, rest assured that our lyophilizers are ready to order – for faster than average market delivery.

Built for demanding lyophilization needs – Each of our units can accommodate vials up to 100 mL. You can therefore develop the most aggressive of freeze-drying cycles safe in the knowledge that you’re using a lyophilizer that works with you.
State-of-the-art lyophilization technologies – To help you overcome the mounting challenges when scaling up your lyophilization processes for development, all SP Hull LyoConstellation™ Production Lyophilizers are compatible with our Line of Sight™ suite of scalable lyophilization tools that incorporate Process Analytical Technologies (PAT) to automate, control, and support the lyophilization process. This guarantees efficiency, quality and consistency throughout the entire fill-finish process.

SP’s Line of Sight PAT Tools:
LyoFlux® TDLAS
Let the data guide you! Measure water vapor mass flow with accuracy during freeze-drying
SMART™ Freeze Dryer Technology
No hesitation – get instant feedback on important product data including resistance, heat flow, and mass transfer
TEMPRIS® Wireless Sensors
Advanced wireless temperature monitoring for the highest quality product – on budget and on time
ControLyo® Nucleation Technology
Take control of your freeze-drying with cutting-edge nucleation technology – for precise control of the freezing point
SP Hull LyoConstellation™ Production Lyophilizer models:
Shelf area of 8 m²
7 shelves
Shelf area of 10 m²
9 shelves
Shelf size of 13 m²
12 shelves
Please note: Our SP Hull LyoConstellation™ Pilot Lyophilizers also come with 5, 6 and 8 shelves if you need a lower throughput solution

Application Examples

  • Therapeutic Proteins
  • ADC Production for Clinical Trials
  • Medium Batch Production for Compounding Pharmacies and Pharma, Including CMO and CRO
  • Diagnostics