The Benefits of Microfluidic Modulation Spectroscopy (MMS)
What is MMS technology?
- Novel, fully automated technique providing ultra-sensitive, ultra-precise structural measurements of proteins and biomolecules
- Accurate and reproducible measurements with broad concentration range from 0.1 mg/mL to >200 mg/mL allows measurements in native conditions
- 20x faster and 30x more sensitive to changes in structure than CD or FTIR*
- Real-time buffer subtraction minimizes background noise and interference from excipients
Why add MMS into your development workflow?
- DISCOVERY: Incorporate structural monitoring to add more robust selection criteria for candidate screening
- FORMULATION: Automatically analyze and compare samples across a formulation study to predictively identify optimal buffer formulations, stability profiles, and storage conditions before locking in conditions eliminating costly downstream failures.
- MANUFACTURING: Track stability and structure as Critical Quality Attributes (CQAs) across the entire manufacturing process to guarantee safety, efficacy, and functionality
The BENEFITS of measuring HIGHER ORDER STRUCTURE
- Track and maintain the critical relationship between structure and function from Discovery to Formulation to Manufacturing securing a faster route to market
- Identify conditions and process steps that introduce undesired structural changes or aggregation due to intermolecular interactions
- Add meaning to changes in inactivity due to detected changes in folding at the secondary structural level
- Improve quality through all stages of the development process by monitoring stability and similarity
How MMS adds value to your development toolkit
By incorporating MMS into your analytical suite of tools, you will add the value of monitoring stability, structure, similarity, and intermolecular aggregation all measured from a single automated run powered by ultra-high precision fluidics and detection, and processed using a state-of-the-art intuitive analytical engine.