SEQUEL IIe SYSTEM Long-read sequencing

The PacBio Sequel II and IIe systems provide all scientists with access to high throughput, cost effective, highly accurate long-read sequencing. Watch this short video to learn how the Sequel II and IIe systems can help you be confident in your discoveries made possible with comprehensive views of genomes, transcriptomes, and epigenomes.

Long, accurate HiFi reads with DNA methylation direct from the instrument in every run

Supports a wide range of applications – targeted sequencing, RNA sequencing, and whole-genome sequencing

Throughput match for microbial genome sequencing, AAV vector sequencing, Iso-Seq, and more

Featured in hundreds of peer-reviewed publications


  • Automated consumable handling with integrated software
  • Intuitive run setup and monitoring
  • Flexible runtime
  • Data available for analysis as each SMRT Cell completes
  • Fully automated: No manual touch points during a sequencing run

* Number of HiFi reads is dependent upon the insert size and sample quality