LCMS-8045

LCMS-8045, Liquid Chromatograph-Mass Spectrometer is an optimum balance of sensitivity, speed and robustness. The system features a heated ESI probe, high-temperature heating block, heated desolvation line, drying gas and focusing optics all acting to maximise sensitivity and achieve superior performance.

High Sensitivity and Ultra Speed Detection

With Highest sensitivity in its class and maintaining Ultra Speed LCMS-8045 provides accurate data over longer periods of time.  Inclusion of Shimadzu’s ultra-high-speed high-voltage power supply enables the world’s fastest*scan speed (30,000 u/s) and polarity switching time (5 ms) resulting in increased through-put and shortens method development.

Consistent High Performance Over Varied Conditions.

• Robust Ion Source.

Shimadzu’s MS interface includes a high-sensitivity heated ESI source, heated capillary sample introduction, and proprietary ion transfer optics. These design features combine to produce robust MS performance. 12,000 plasma samples were injected over 25 days (over 480 samples per day). Picogram levels of alprazolam were analyzed with an RSD of 3.42%

• High Performance over variety of Applications.

Because of the Robustness of LCMS 8045, the instrument can be used in varied conditions and a variety of applications which include Veterinary Drugs, Residual Pesticides, Water Quality Analysis, Bio-analysis among others.

• Instrument Detection Limits

IDL is one measure of sensitivity for analytical instrumentation. The chromatograms below show the IDL for Reserpine and Chloramphenicol, obtained using ESI+ and ESI−, respectively. The IDL for Reserpine is 2.03 femtograms and 2.09 femtograms for Chloramphenicol.

Easy System Maintenance Reduces Downtime

• Newly Designed Ionization Unit

Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS™ units, allowing for easy maintenance.

As with Shimadzu’s other triple quad systems, maintaining the LCMS-8045 is simple. Replacing the desolvation line (DL) and ESI capillary is quick and easy. Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability.

Lab Solutions Connect

LabSolutions Connect is the smart way to work for all routine laboratories. Simplifying workflows to run samples on the LC-MS/MS with tools to help MRM optimization using its unique features such as

• Tablet like UI for Sample analysis
• Survey Panel view
• New way to view Data
• Optimising better results

The automated MRM optimization tool, which is part of the LabSolutions Connect platform, delivers MRM transitions for quantitation and for MRM Spectrum for library searchable identification.

LC/MS/MS Method Packages and MRM Libraries

A variety of method packages and MRM libraries, which include analysis conditions such as MRM parameters, enable efficient implementation of simultaneous multi-component analyses. The method parameter list included in these packages can be used to create methods that analyze targeted components only. These packages can save laboratories a great deal of method development time.