LCMS-9030
The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer integrates the world’ s fastest and most sensitive quadrupole technology with TOF architecture. A product of Shimadzu’s engineering DNA, speed and effortless performance enable the LCMS-9030 to address qualitative and quantitative challenges with genuine confidence and ease. High-efficiency ion guides, quadrupole, and collision cell enable high sensitivity for the detection of trace-level compounds.
Unique UFgrating and iRefTOF technologies ensure ultrafast acceleration of ions into the fiight tube (UF-FlightTube) and ideal reflection of those ions back to the detector. The result is high-speed data acquisition compatible with the high-throughput laboratory.
Effortless Performance for Accurate Mass
Mass measurement accuracy (MMA) is the key performance attribute underlying all application fields using high-resolution accurate-mass (HRAM) spectrometers. The LCMS-9030 delivers the MMA needed for high-confidence identification of unknown compounds at an unprecedented level of stability. This is made possible by new technologies implemented in the Intelligent Temperature Control System and the UF-FlightTube that accurately offset the changes occurring to both internal and external environments. With the LCMS-9030, Shimadzu aims to totally refashion the HRAM user experience, enabling scientists to run more samples at longer calibration intervals with greater confidence and ease.
Effortless Performance for Accurate Mass
Genuine ion statistics ensure that all measurements throughout the peak elution result within a narrow m/z window of the extracted ion chromatogram (XIC), as shown below for Verapamil analysis. Even at 10 fg injection, the overall mass error was less than 1 ppm and all data points gave results within the 5 ppm XIC window for accurate, repeatable and selective quantitation. Moreover, stability of MMA allows the same XIC setting to be comfortably used for series of analyses.
Same MMA Across Acquisition Modes
MS/MS spectra are a key tool for structural elucidation of unknown compounds, and ease of data interpretation is directly dictated by the MMA of MS/MS acquisition. This makes the LCMS-9030 an ideal instrument for structural analysis as its MS/MS mode achieves equally high MMA as the MS mode, thanks to the collision cell technologies that generate high-abundance fragment ions.
The results of MS/MS structural analysis of cyclosporine are shown below. Numerous ions were matched with putative fragment structures at less than 1 mDa mass error. Formula prediction results for m/z 567.3860 at different mass error tolerances demonstrate the impact of MS/MS MMA in making the prediction unambiguous.
LabSolutions™ LCMS Software, A Simple Analytical Platform
LabSolutions LCMS is your single point of control for UHPLC and mass spectrometry data acquisition and data analysis. Intuitive icons and a common user interface with Shimadzu’s quantitative LC-MS platform make accurate mass data analysis with the LCMS-9030 easy to perform. Qualitative and quantitative acquisition modes that fully utilize the capability of the LCMS-9030 are MS, SIM, MS/MS, MRM, and MS/MS (DDA*). Three of these modes, MS/MS, MRM, and MS/MS (DDA), allow the user to fully customize settings such as quadrupole isolation resolution. Users will find easy yet flexible workflows with the LCMS-9030 Q-TOF.
Ion accumulation in the collision cell, synchronized perfectly with short cycles of data acquisition, maximizes sensitivity
Shimadzu’s world-class manufacturing capability has enabled the ion acceleration electrode to be made with substantial mechanical strength. This grating is able to withstand the high voltages needed for ultrafast ion pulsing.
Lossless microchannel plate design maximizes sensitivity.
Mass accuracy needs mass stability. Shimadzu’s temperature-controlled UF-FlightTube requires less frequent calibration, enabling you to run more samples.
A computationally ideal electrostatic field has become a reality. Meticulously manufactured plate electrodes are stacked to create a reflectron which turns ions with no compromise in resolution or sensitivity.