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Sample Preparation

Hamilton – Sample Management Systems
Hamilton Verso systems provide fully automated, ultra-low-temperature storage solutions, integrated with LIMS for precise sample tracking and retrieval. Designed to handle biological samples and compound libraries, these systems streamline workflows, ensuring minimal manual handling errors and secure long-term sample integrity. Ideal for lead identification and high-throughput screening workflows.

Shimadzu Balances
Shimadzu AUW-D series offers high-precision weighing capabilities with auto-calibration technology, delivering unmatched accuracy for reagent preparation and assay development. These balances ensure reproducible results in preparing drug compounds and critical solutions for experimental workflows.

Kinematica Homogenizer
The Polytron PT 3100 series utilizes rotor-stator technology with precise speed control for consistent homogenization of biological samples, including tissues and cells. It supports efficient extraction of biomolecules like proteins and nucleic acids, making it an essential tool for preclinical research and proteomics workflows.

Sonicator
QSonica Q700, with programmable amplitude and pulse control, provides precise ultrasonic energy for sample preparation. It is widely used for cell disruption, nanoparticle dispersion, and emulsion preparation in preclinical drug delivery studies, ensuring uniform sample processing.

Gyrozen Centrifuge, Concentrator, and Lyophilizer
Gyrozen 1236R features advanced rotor options and temperature control for versatile applications. Centrifuges enable fractionation of biomolecules and cell components, while concentrators ensure rapid sample concentration. Lyophilizers preserve bioactive compounds for long-term storage, crucial for stability studies.

High-Throughput Screening and Analysis

Sony Flow Cytometry (ID7000)
The ID7000 offers spectral flow cytometry with multicolor detection for phenotypic analysis, immune profiling, and rare cell detection. Its ability to analyze up to 40 markers simultaneously accelerates biomarker discovery and cellular assay screening.

Victor Nivo Revvity
Compact and versatile, this multi-mode plate reader supports fluorescence, luminescence, and absorbance-based assays. It enables high-throughput screening of chemical and biological compounds for hit-to-lead optimization and IC50 determination in drug discovery.

Cytiva Via Extractor
A closed automated nucleic acid extraction system, VIA Extractor delivers high-purity RNA/DNA for genomic studies. This ensures reproducible results in target validation workflows, including CRISPR and gene-editing research.

Compound Separation and Purification

Shimadzu Preparative HPLC (LC-40)
With modular and scalable options, Shimadzu LC-40 systems offer precise fraction collection and high throughput. This system is widely adopted for purifying APIs, intermediates, and impurities, ensuring high-purity isolates for bioavailability studies.

Shimadzu SFC – Nexera UC
Using eco-friendly supercritical CO2 as a mobile phase, the Nexera UC provides efficient chiral separation and enantiomer purification. Its green technology is ideal for stereoselective drug development workflows.

Shimadzu Prep SFC (Nexera Prep)
Nexera Prep offers high-capacity chiral purification with superior resolution and scalability. This system supports preclinical synthesis by purifying complex intermediates while maintaining high yield and purity.

Analytical Characterization and Identification

Shimadzu LCMS 2050 Compact MS
A miniaturized MS with ultra-fast scanning, the LCMS 2050 is perfect for routine analysis of small molecules and impurities. It delivers reliable results in complex matrices, essential for early drug candidate profiling.

Shimadzu LCMS 8060RX for DMPK Labs
This ultra-fast triple-quadrupole MS system features enhanced ion guides for trace-level detection, enabling ADME studies, bioavailability analysis, and metabolite identification. It is critical for pharmacokinetic profiling in preclinical and clinical studies.

ATS Freeze Dryers (Benchtop Model)
Compact and efficient, ATS freeze dryers provide advanced temperature control for stable sample storage. They ensure bioactive compounds remain intact for analytical and long-term use.

Shimadzu ELSD 100LT
The ELSD 100LT enables detection of non-UV-active compounds, including lipids and carbohydrates, through evaporative light scattering. This system expands analytical capabilities for compound libraries in drug discovery.

Method Development and Process Optimization

Shimadzu Ai-Series 3D with QbD
Integrating advanced 3D simulation and quality-by-design (QbD) principles, Ai-Series 3D optimizes analytical methods for regulatory compliance. It is a powerful tool for robust method development in early drug discovery.

Shimadzu MDAP
The Mass-Directed Automated Purification (MDAP) system features automated method optimization for chromatographic and MS-based workflows. It ensures high-yield purification of complex samples, streamlining validation processes.

ASA Prep
ASA Prep systems offer high-efficiency purification for APIs and other compounds, ensuring GMP compliance. These systems are widely used for advanced purification needs in drug manufacturing pipelines.

Shimadzu UFPLC
The UFPLC combines ultra-filtration with FPLC technology for high-precision purification of biomolecules. This system is essential for isolating proteins and peptides in biologics development.

Data Management and Integration
Shimadzu LabSolutions Network Software
LabSolutions software centralizes control of multiple instruments with built-in regulatory compliance features like FDA 21 CFR Part 11. It ensures seamless data acquisition and processing, supporting reproducibility and traceability.

Shimadzu Open Solutions Software
With an open architecture, Open Solutions integrates data from diverse platforms. It facilitates collaborative workflows, enabling efficient decision-making and accelerated drug discovery.